Geriatric depression consists of complex and heterogeneous behaviors unlikely to be
caused by a single brain lesion. However, there is evidence that abnormalities in specific
brain structures and their interconnections confer vulnerability to the development of late-life
depression. Structural magnetic resonance imaging methods can be used to identify and
quantify brain abnormalities predisposing to geriatric depression and in prediction of
treatment response. This article reviews several techniques, including morphometric …